Deadpool By Posehn & Duggan Volume 4 - Brian Posehn, Gerry Duggan

It's the end of the road for the Merc with a Mouth! First, the red-clad hero is stalked by a classic Spider-Slayer! But this isn't a Spider-Man book. Deadpool had better find out what's going on before it mashes him into spider-paste! Then, inverted by the events of Axis, Deadpool puts down the guns. and goes Zen! So how can he possibly save his friends from an attack by the also-inverted X-Men? Oh and he dies at the end. Is that a spoiler?